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Clinical Studies |
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Proceptin®
is a result of over 60 research studies addressing the role
of metabolic intermediaries, anti-oxidants in male reproduction. Provided below are a variety
of the studies that have looked at the role of nutritional
supplements improving sperm parameters.
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- Balercia G, Arnaldi G, Fazioli F, et alt.:
Coenzyme Q10 levels in idiopathic and varicocele-associated
asthenozoospermia. Andrologia. 2002 Apr;34(2):107-11.
- Bayer R. Treatment of infertility
with vitamin E. Int J Fertil 1960; 5:70–8.
- Bentivoglio
G, Melica F, Cristoforoni P: Folinic acid in the treatment
of human male infertility. Fertil Steril. 1993 Oct;60(4):698-701.
- Chen JC, Chen LD, Tsauer
W, et al.: Effects of Ginsenoside Rb2 and Rc on inferior
human sperm motility in vitro. Am J Chin Med. 2001;29(1):155-60.
- Chen JC, Xu MX, Chen LD,
et al.: Effect of panax notoginseng extracts on inferior
sperm motility in vitro. Am J Chin Med. 1999;27(1):123-8.
- Costa M, Canale D, Filicori
M, et alt.: L-carnitine in idiopathic asthenozoospermia:
a multicenter study. Italian Study Group on Carnitine and
Male Infertility. Andrologia. 1994 May-Jun;26(3):155-9.
- Dandekar SP, Nadkarni GD,
Kulkarni VS, et al.: Lipid peroxidation and antioxidant
enzymes in male infertility. J Postgrad Med. 2002 Jul-Sep;48(3):186-89;
discussion 189-90.
- Dawson EB,
Harris WA, Powell LC. Relationship between ascorbic acid
and male fertility. In: Aspects of Some Vitamins, Minerals
and Enzymes in Health and Disease, ed. GH Bourne. World
Rev Nutr Diet 1990; 62:1–26 [review]
- Dawson EB, Harris WA, Teter
MC, et alt.: Effect of ascorbic acid supplementation on
the sperm quality of smokers. Fertil Steril. 1992 Nov;58(5):1034-9.
- Fraga, C.G., Motchnik, P.A.,
Shigenaga, M.K., Helbock, H.J., Jacob, R.A., and Ames, B.N.
Ascorbic Acid Protects Against Endogenous Oxidative DNA
Damage in Human Sperm. Proceedings of the National Academy
of Sciences, Dec. 1991; 88: 11003-11006.
- Gagnon, C., Iwasaki, A.,
Lamirande, E.D., and Kovalski, N. Reactive Oxygen Species
and Human Spermatozoa. Annals of the New York Academy of
Sciences, 1991; 637: 436-44.
- Geva, Bartoov B, Zabludovsky
N, et al. The effect of antioxidant treatment on human spermatozoa
and fertilization rate in an in vitro fertilization program.
Fertil Steril 1996; 66:430–4.
- Goverde HJ, Dekker HS, Janssen
HJ, Bastiaans BA, Rolland R, Zielhuis GA: Semen quality
and frequency of smoking and alcohol consumption - an explorative
study. Int J Fertil 1995; 40:135–8.
- Halliwell, B. Reactive Oxygen
Species in Living Systems: Source, Biochemistry, and Role
in Human Diseases. The American Journal of Medicine, Sept.
30, 1991; 91: 3C-14S--3C-22S.
- Hunt CD, Johnson PE, Herbel
JoL, Mullen LK. Effects of dietary zinc depletion on seminal
volume and zinc loss, serum testosterone concentrations,
and sperm morphology in young men. Am J Clin Nutr 1992;
56:148–57.
- Isoyama R, Kawai S, Shimizu
Y, et al.: Clinical experience with methylcobalamin (CH3-B12)
for male infertility Hinyokika Kiyo. 1984 Apr;30(4):581-6.
Japanese.
- Iwanier K, Zachara BA: Selenium
supplementation enhances the element concentration in blood
and seminal fluid but does not change the spermatozoal quality
characteristics in subfertile men. J Androl. 1995 Sep-Oct;16(5):441-7.
- Iwasaki, A., and Gagnon,
C. Formation of Reactive Oxygen Species in Spermatozoa of
Infertile Patients. Fertility and Sterility, Feb. 1992;
57(2): 409-416.
- Kessopoulou E; Powers HJ;
Sharma KK; Pearson MJ; Russell JM; Cooke ID; Barratt CL:
A double-blind randomized placebo cross-over controlled
trial using the antioxidant vitamin E to treat reactive
oxygen species associated male infertility. Fertil Steril
(United States), Oct 1995, 64(4) 825-31
- Lewin A, Lavon H: The effect
of coenzyme Q10 on sperm motility and function. Mol Aspects
Med. 1997;18 Suppl:S213-9.
- Lenzi A, Lombardo F, Sgro
P, et al.: Use of carnitine therapy in selected cases of
male factor infertility: a double-blind crossover trial.
Fertil Steril. 2003 Feb;79(2):292-300.
- Lewis, S., Boyle, P.M.,
McKinney, K.A., Young, I.S., Thompson, W. Total Antioxidant
Capacity of Seminal Plasma is Different in Fertile and Infertile
Men. Fertility and Sterility, Oct. 1995; 64(4): 868-70.
- Marmar JL, Katz S, Praiss
DE, DeBenedictis TJ. Semen zinc levels in infertile and
postvasectomy patients and patients with prostatitis. Fertil
Steril 1975:26:1057–63.
- Miura K, Matsuhashi M, Maki
A, et alt.: [Clinical experience of Hachimijiogan for male
infertility patients] Hinyokika Kiyo. 1984 Jan;30(1):97-102.
Japanese.
- Netter A, Hartoma R, Nahoul
K. Effect of zinc administration on plasma testosterone,
dihydrotestosterone and sperm count. Arch Androl 1981;7:69–73.
- Nishizawa Y: [The effect
of Chinese drug therapy on the patients with male infertility.
1. Concomitant administration of ninjinto and hachimijiogan
on patients with male infertility] Hinyokika Kiyo. 1984
Feb;30(2):265-73. Japanese.
- Qian YX, Shen PJ, Xu RY,
et alt.: Spermicidal effect in vitro by the active principle
of garlic. Contraception. 1986 Sep;34(3):295-302.
- Rolf C, Cooper TG, Yeung
CH, et alt.:. Antioxidant treatment of patients with asthenozoospermia
or moderate oligoasthenozoospermia with high-dose vitamin
C and vitamin E: a randomized, placebo-controlled, double-blind
study. Hum Reprod. 1999 Apr;14(4):1028-33.
- Roseff SJ.: Improvement
in sperm quality and function with French maritime pine
tree bark extract. J Reprod Med. 2002 Oct;47(10):821-4.
- Scott R, MacPherson A, Yates
RW, et alt.: The effect of oral selenium supplementation
on human sperm motility. Br J Urol. 1998 Jul;82(1):76-80.
- Sinclair S: Male infertility:
nutritional and environmental considerations. Altern Med
Rev. 2000 Feb;5(1):28-38. Review.
- Takayama H, Konishi T, Kounami
T, et alt.: Clinical effects of goshajinkigan for male infertility.
Hinyokika Kiyo. 1984 Nov;30(11):1685-9. Japanese.
- Tsvetkov D. [The treatment
of male infertility with the preparation vitaton] Khirurgiia
(Sofiia). 1989;42(6):49-52. Bulgarian.
- Vezina D, Mauffette F, Roberts
KD, et alt.: Selenium-vitamin E supplementation in infertile
men. Effects on semen parameters and micronutrient levels
and distribution. Biol Trace Elem Res. 1996 Summer;53(1-3):65-83.
- Wong WY, Merkus HM, Thomas
CM, et alt.: Effects of folic acid and zinc sulfate on male
factor subfertility: a double-blind, randomized, placebo-controlled
trial. Fertil Steril. 2002 Mar;77(3):491-8.
- Zheng RL, Zhang H: Effects of ferulic acid
on fertile and asthenozoospermic infertile human sperm motility,
viability, lipid peroxidation, and cyclic nucleotides. Free
Radic Biol Med. 1997;22(4):581-6.
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